High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market (2025 - 2035) Size, Share & Trends Analysis Report By Frequency Type (Low-field NMR Spectroscopy, High-field NMR Spectroscopy), By Application, By End-use, By Region, And Segment Forecasts

High & Ultra-high-field NMR Spectroscopy Market Summary

The global high and ultra-high-field nuclear magnetic resonance spectroscopy market size was estimated at USD 561.67 million in 2024 and is projected to reach USD 1,033.67 million by 2035, growing at a CAGR of 5.65% from 2025 to 2035. Market growth can be attributed to the increasing funding & investment initiatives for nuclear magnetic resonance (NMR) spectroscopy in biomedical research, the rising need for affordable generic medicines, the growing scope of NMR spectroscopy in non-healthcare sectors, aided by the rising adoption of the technique in medical diagnosis.

Nuclear Magnetic Resonance (NMR) spectroscopy is an effective method for assessing crystalline and amorphous pharmaceuticals in both drugs and their finished products. The development of generic medicines is expected to increase demand for NMR, as it supports essential processes in the pharmaceutical industry, such as drug substance characterization, determination of crystalline structures, and monitoring of form conversion during active pharmaceutical ingredient (API) scale-up. Solid-state NMR (SSNMR) is vital for investigating multiple crystalline forms in APIs and drug products. With drug development activity continuing to grow, the requirement for NMR spectroscopy is set to rise significantly, supported by universities, product developers, and pharmaceutical service providers.

NMR spectroscopy is also expanding its role in diagnostics and biomedical research. The technique allows the study of peptides, proteins, nucleic acids, and amino acids, providing insights into their structure, dynamics, and molecular interactions. As research in the biomedical field increases, the use of NMR is expected to accelerate. According to the World Health Organization (WHO), the number of funders and their contributions to biomedical research have been growing steadily since 2012. In 2020, about 74,702 grants were awarded, with the U.S. National Institutes of Health (NIH) providing the largest share. This steady growth in funding highlights the importance of NMR as a widely used tool in biomedical science.

NMR has gained attention in medical diagnosis due to its nondestructive, noninvasive nature and simple sample preparation. These qualities make it highly effective for metabolomics studies. Research has explored its use in diagnosing Parkinson’s disease, cancer, infectious conditions, and psychiatric disorders. Companies and academic institutions are actively developing metabolomics-based diagnostic tools using NMR. For example, in January 2022, the University of Oxford developed a blood test based on NMR metabolomics to detect various cancers. Similarly, Lifespin, a metabolomics testing company, reported in 2021 that it had created NMR-based metabolic profiles for about 130,000 individuals across multiple disease cohorts, providing a foundation for developing diagnostic applications. These initiatives show the growing focus on NMR in clinical research and diagnostics.

Technological advancements are now complementing this rising adoption. In April 2025, Bruker Corporation announced the world’s first 1.3 GHz high-resolution NMR spectrometer at the Joint ENC-ISMAR Conference. Installed at its ultra-high field facility in Fällanden, Switzerland, the spectrometer is based on a hybrid low-temperature (LTS) and high-temperature (HTS) superconducting magnet architecture. Delivering a field strength of 30.5 Tesla with a novel ReBCO HTS insert, the 1.3 GHz instrument provides unprecedented resolution and sensitivity while maintaining the same footprint and cryogen efficiency as Bruker’s 1.2 GHz systems.

Application testing confirmed the versatility of the platform, with high-resolution spectra obtained for both liquid and solid-state samples across multiple probe configurations, including advanced ultra-fast spinning MAS probes. The stronger magnetic field offers unique benefits for biomolecular research, particularly in studying carbohydrates, glycoproteins, RNA, and intrinsically disordered proteins (IDPs). Direct ^13C and ^15N detection of IDPs demonstrated clear sensitivity gains, opening new approaches for studying molecular dynamics and function at atomic resolution. In solid-state applications, the enhanced field narrowed spectral lines for quadrupolar nuclei and improved chemical shift tensor measurements, providing powerful capabilities for complex materials research.

“Reaching 1.3 GHz is yet another milestone in Bruker’s commitment to innovation,” said the President of the Bruker BioSpin Group. “Our GHz-class NMRs enable researchers to advance their understanding of complex biomolecular systems while supporting major breakthroughs in materials science, particularly for compounds with quadrupolar and low-gamma nuclei.”

Early adopters confirmed the impact of the technology. The RIKEN Yokohama Institute in Japan reported a remarkable gain in resolution and sensitivity for protein and nucleic acid samples. At the same time, CEMHTI-CNRS Orléans, France, highlighted dramatic improvements in resolving atomic environments in materials.

The broad use of NMR in pharmaceuticals, the steady rise in biomedical research funding, the growing interest in metabolomics-based diagnostics, and technological milestones such as Bruker’s 1.3 GHz spectrometer are reshaping the field. NMR spectroscopy is now firmly positioned as a cornerstone technology driving life sciences and materials research progress.

Market Concentration & Characteristics

The degree of innovation in the market is high, representing a significant advancement in structural biology, metabolomics, and material science. The introduction of GHz-class NMR spectrometers, capable of achieving magnetic fields up to 1.2 GHz, has revolutionized the resolution and sensitivity of NMR experiments. These advancements allow for the separation of complex spectra, enhancing the accuracy of structure determination and improving the detection of low-concentration samples. The development of these technologies is driven by the need for sensitivity and specificity in NMR experiments, overcoming the limitations imposed by the inherent low sensitivity of NMR.

The level of M&A activity in the market is moderate due to its concentration with a limited players. These entities engage in mergers and acquisitions to enhance their industry standing, strengthening their capabilities and competencies. For instance, in April 2022, Bruker acquired the UK-based Optimal Industrial Automation and Technologies. The tools and automation capabilities of acquired companies are expected to complement Bruker Corporation’s novel and differentiated high-value NMR instruments.

Regulations have a high impact on the market. Regulations play a crucial role in the NMR Spectroscopy market, affecting its competitive landscape by limiting the number of competitors and protecting established players' interests. Compliance with these regulations can be challenging and costly, impacting companies' profitability. However, favorable guidance and policies from regulatory authorities for utilizing NMR spectroscopy in medical applications are expected to boost the industry over the next decade. Yet, regulation changes introduce uncertainties for industry participants, potentially requiring significant investments to meet new compliance requirements.

The threat of substitutes is expected to be high in this market due to external substitutes such as mass spectrometry and High-performance Liquid Chromatography (HPLC) with conventional ultraviolet detection. However, fewer benefits associated with using these substitutes decrease the threat to a certain level, leading to a moderate overall threat.

The market's regional expansion is characterized by significant growth opportunities across different regions. North America, particularly the U.S., holds a substantial share due to numerous universities and government funding support for enhancing research infrastructure. Europe, led by the UK, Germany, France, Italy, and Spain, contributes significantly to the market's growth.

Frequency Type Insights

Ultra-high-field NMR Spectroscopy (600-1200 MHz) segment led the market and accounted for 65.96% of the global revenue in 2024, driven by its advanced technological capabilities and expanding applications in various scientific fields. This range is crucial for detailed molecular and structural analysis, making it indispensable in pharmaceutical research, material science, & academic research. The pharmaceutical industry is a significant driver of the segment. As drug discovery processes become more complex, the need for detailed structural elucidation of large biomolecules such as proteins and nucleic acids increases. NMR in the 600 to 1.2 GHz range provides the detail, resolution, and sensitivity data required to study these complex molecules. This capability is essential for understanding drug-target interactions, optimizing lead compounds, and ensuring the structural integrity of biologics.

The high-field NMR spectroscopy (300-600 MHz) segment held a significant market share in 2024, fueled by technological advancements and a surge in demand across various sectors. This range of NMR spectroscopy is extensively utilized in organic chemistry, biochemistry, and pharmaceuticals due to its ability to provide detailed molecular structure information. The market is projected to grow steadily, primarily driven by the expanding pharmaceutical and biotechnology industries. A significant driver is the need for precise structural analysis of compounds in drug discovery and development. In addition, the rise in academic research activities and increased investments in scientific research by governments and private organizations further contribute to market expansion.

Application Insights

The academic research segment led the market and accounted for 33.79% of the global revenue in 2024. In academic research, NMR spectroscopy is used across various disciplines, including structural biology, metabolomics, materials science, environmental science, and biomedical research. This technology provides detailed insights into a molecule’s structure, function, and interactions, significantly contributing to advancements in knowledge and innovation. In structural biology, NMR spectroscopy explains the three-dimensional structures of proteins and nucleic acids, offering critical insights into their functions and interactions.

The pharmaceutical application segment is projected to grow significantly over the forecast period. In the pharmaceutical industry, it is primarily used in comparative analysis, quantification, and quality control. The growing demand for NMR spectroscopy can be attributed to its ability to determine the content and test the purity of the sample. Furthermore, increasing penetration in chemical and biochemical labs to investigate the characteristics of organic molecules is expected to drive the NMR spectroscopy market.

End-use Insights

Academic led the market with a market share of 33.79% in 2024. High-field NMR spectroscopy significantly benefits academic research by providing detailed insights into molecular structures, assisting in drug discovery, & enhancing our comprehension of diseases such as cancer & Parkinson's. Its utility in structural biology and identifying complex molecules, including those associated with COVID-19, emphasizes its vital role in tackling global health issues. The rising demand in academic circles is likely to propel market growth, spurred by technological advancements and a growing focus on structural biology. Government funding for research infrastructure further boosts market expansion, emphasizing the crucial function of NMR in academic progress & market growth. For instance, in June 2021, the U.S. National Science Foundation (NSF) invested USD 40 million in a geographically distributed Network for Advanced Nuclear Magnetic Resonance to boost biomolecular research. This initiative, part of the NSF's Mid-Scale Research Infrastructure II program, sought to equip researchers with NMR spectrometers for studying biological systems and small molecules' structure, dynamics, and interactions.

The pharmaceutical and biotech companies segment is projected to grow significantly over the forecast period. Biotech and pharmaceutical companies are extensively utilizing technology in their operations, particularly in the early stages of drug discovery & development. This technology is crucial for assessing macromolecules' structure, dynamics, and interactions, essential for understanding the molecular basis of diseases & designing targeted therapies. Integrating NMR with other analytical techniques, such as mass spectrometry and chromatography, can enrich the data obtained, providing a comprehensive view of complex samples & systems. This multifaceted approach has contributed significantly to market growth, driven by the increasing demand for advanced analytical tools in the biotech and pharmaceutical sectors. For instance, in August 2022, Covalent Metrology installed a new 500 MHz NMR Spectrometer from JEOL. This installation enhanced Covalent's ability to support clients across various industries by providing solid-state & diffusion NMR services, including batteries, polymers, and carbon-capture materials.

Regional Insights

The North America high and ultra-high-field nuclear magnetic resonance spectroscopy market is significantly growing, influenced by healthcare reforms and research advancements. This can be attributed to a well-established pharmaceutical industry and healthcare system in the U.S., which has created a significant demand for clinical & research purposes.

U.S. High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market Trends

The high and ultra-high-field nuclear magnetic resonance (NMR) spectroscopy market in the U.S. is anticipated to experience lucrative growth during the forecast period, as it is the biggest market for biopharmaceuticals and a leader in biopharmaceutical R&D. According to the data published by PhRMA in 2022, member companies invested USD 102.3 billion in R&D of new medicines. Member companies have invested about USD 1.1 trillion in the R&D of new medicines over the last 20 years.

Europe High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market Trends

Europe high and ultra-high-field nuclear magnetic resonance (NMR) spectroscopy market accounted for the largest market share of 34.78% in 2024, which can be attributed to the well-established pharmaceutical & biotechnology industries across Germany, UK, and Italy, and increasing demand for technology. Moreover, expanding the biotechnology & pharmaceutical sector in countries such as Spain and Russia is expected to create a conducive environment for market growth in Europe. In addition, continuous research initiatives being undertaken by European manufacturers for the development of new and innovative NMR solutions are anticipated to create lucrative opportunities for market growth.

The high and ultra-high-field nuclear magnetic resonance spectroscopy market in the UK is witnessing significant developments and a growth trend, driven by established R&D infrastructure and government investments. The UKRI infrastructure supports the resources, tools, and facilities researchers and innovators need to carry out groundbreaking work in the UK.

The France high and ultra-high-field nuclear magnetic resonance spectroscopy marketis poised for growth, driven by research and development in biological sciences. As a result of this vibrant atmosphere, several exceptional businesses have developed, reaching the value chain.

The high and ultra-high-field nuclear magnetic resonance spectroscopy market in Germanyis driven by favorable government regulations, advanced healthcare infrastructure, a rising number of drug & device approvals, and growing concerns regarding food safety are some key factors driving the market.

Asia Pacific High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market Trends

The high and ultra-high-field nuclear magnetic resonance (NMR) spectroscopy market in Asia Pacific is experiencing significant growth attributed to expanding the pharmaceutical & biotechnology industries in emerging economies, such as China and India. The robust growth is further propelled by consistent government support for advancing the pharmaceutical sector in developing nations.

China high and ultra-high-field nuclear magnetic resonance (NMR) spectroscopy marketis expected to grow at a lucrative rate during the forecast period. This can be attributed to the robust growth of China's pharmaceutical, biotechnology, and biopharmaceutical sectors.

The high and ultra-high-field nuclear magnetic resonance spectroscopy market in Japanhas experienced considerable development, positioning Japan to hold a substantial share of the Asia Pacific market. This is largely attributed to Japan's developed pharmaceutical and biotechnology sectors, which drive the demand for advanced analytical tools.

Latin America High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market Trends

The high and ultra-high-field nuclear magnetic resonance (NMR) spectroscopy market in Latin America is influenced by technological advancements, increasing government expenditure on R&D, the presence of skilled healthcare professionals, and the rising focus of multinational pharmaceutical companies on analytical instruments.

Brazil high and ultra-high-field nuclear magnetic resonance spectroscopy market is attributed to the presence of an established pharmaceutical industry compared to other countries in Latin America. Furthermore, increasing public-private initiatives to facilitate access to advanced NMR spectroscopy solutions are expected to drive market growth.

MEA High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market Trends

The high and ultra-high-field nuclear magnetic resonance spectroscopy market in Middle East & Africa is witnessing a gradual increase in use; however, at different rates. Leading nations, including Saudi Arabia, the United Arab Emirates (UAE), Qatar, South Africa, and Egypt, are advancing the integration of cutting-edge NMR technology into their scientific research infrastructure. The market is experiencing a gradual increase in adoption. Key countries such as Saudi Arabia, the UAE, Qatar, South Africa, and Egypt are actively integrating state-of-the-art NMR technology into their scientific research infrastructures.

Saudi Arabia high and ultra-high-field nuclear magnetic resonance (NMR) spectroscopy marketgrowth can be attributed to various initiatives being undertaken by the government to expand the biotechnology sector in the country. Organizations such as King Saud University (KSU) and King Abdullah University of Science & Technology (KAUST) are focusing on investing in facilitating biotechnology R&D activities in Saudi Arabia. Moreover, the increasing private & public partnerships for expanding the biopharmaceutical industry are anticipated to boost product demand.

Key High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Company Insight

The market is largely driven by two major players, Bruker Corporation and JEOL Ltd. These players are adopting acquisitions and other strategies to strengthen their presence in other regional markets.

Recent Developments

• In April 2024, Bruker Corporation unveiled new magnet technology and analytical solutions to enhance the adoption of NMR in academic research, clinical studies, and biopharma drug discovery, development, and Process Analytical Technologies (PAT). Bruker Corporation introduced the Ascend Evo 600, a compact 54 mm standard-bore 14.1 Tesla (600 MHz) NMR magnet with a 1-year liquid helium hold-time, significantly extending refill intervals. The Ascend Evo 600 is the latest in the Evo magnet series, which comprises compact magnets operating at 1 GHz, 900 MHz, 500 MHz, and 400 MHz at 4.2 K. This new magnet features advanced cryogenic technology and a superconducting magnet coil, making it easier to install, reducing operational costs, and lowering helium consumption compared to earlier 600 MHz magnets.

• In April 2023, JEOL Ltd. introduced the Cryogen Reclamation System, an NMR peripheral equipment, to decrease the evaporation of liquid helium in the superconducting magnet. JEOL Ltd. and Japan Superconductor Technology, Inc. jointly developed this product.

• In April 2023, Bruker Corporation unveiled magnet technology and analytical solutions to enhance the adoption of NMR in academic research, clinical studies, biopharma drug discovery & development, and process analytical technologies.

High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market Report Scope

Global High And Ultra-high-field Nuclear Magnetic Resonance Spectroscopy Market Report Segmentation

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2035. For this study, Grand View Research has segmented the global high and ultra-high-field nuclear magnetic resonance spectroscopy market report based on frequency type, application, end-use, and region:

• Frequency Type Outlook (Revenue, USD Million, 2021 - 2035)

  • Low-field NMR Spectroscopy (300-600 MHz)

  • High-field NMR Spectroscopy (600-1,200 MHz)

• Application Outlook (Revenue, USD Million, 2021 - 2035)

  • Pharmaceutical Applications

  • Food & Beverage Testing

  • Biotechnology & Biopharmaceutical Applications

  • Environmental Testing, Academic Research

  • Other Applications

• End-use Outlook (Revenue, USD Million, 2021 - 2035)

  • Academic

  • Pharmaceutical & Biotech Companies

  • Agriculture and Food

  • Chemical Industries

  • Others

• Regional Outlook (Revenue, USD Million, 2021 - 2035)

  • North America

    • U.S.

    • Canada

    • Mexico

  • Europe

    • Germany

    • UK

    • France

    • Italy

    • Spain

    • Denmark

    • Sweden

    • Norway

  • Asia Pacific

    • China

    • Japan

    • India

    • South Korea

    • Australia

    • Thailand

  • Latin America

    • Brazil

    • Argentina

  • Middle East and Africa (MEA)

    • South Africa

    • Saudi Arabia

    • Kuwait

    • UAE